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Comparison of the duration of neuromuscular blockade following a single bolus dose of rocuronium during laparoscopic gynaecological surgery vs conventional open surgery
- Source :
- Anaesthesia. 69:854-859
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Summary We investigated whether laparoscopic vs open surgical approaches affected the duration of neuromuscular blockade following a single bolus dose of rocuronium. Fifty-three female patients underwent either laparoscopic or open gynaecological surgery. Rocuronium 0.6 mg.kg−1 was administered to achieve neuromuscular blockade in all subjects, and adductor pollicis train-of-four responses following ulnar nerve stimulation were monitored with mechanomyography. The mean (SD) time from injection of rocuronium until spontaneous recovery of the first twitch, and to 5% and 25% of baseline, was significantly prolonged in the laparoscopic group (27.2 (8.3) min, 31.3 (9.1) min and 38.1 (10.6) min, respectively) compared with the open surgery group (21.1 (5.8) min, 25.6 (6.3) min and 31.2 (6.7) min, respectively). Changes in liver function both before surgery and at 24 h postoperatively were similar between the two groups (p > 0.05). Our findings suggest that neuromuscular blockade may be prolonged following a single bolus dose of rocuronium given during laparoscopic procedures.
- Subjects :
- Adult
medicine.medical_specialty
Time Factors
Gynecologic Surgical Procedures
medicine
Humans
Androstanols
Rocuronium
Ulnar nerve
Monitoring, Physiologic
Neuromuscular Blockade
Surgical approach
business.industry
Open surgery
Alanine Transaminase
Middle Aged
Gynaecological surgery
Surgery
Anesthesiology and Pain Medicine
Single bolus
Anesthesia
Female
Laparoscopy
Liver function
business
Pneumoperitoneum, Artificial
Neuromuscular Nondepolarizing Agents
medicine.drug
Subjects
Details
- ISSN :
- 13652044 and 00032409
- Volume :
- 69
- Database :
- OpenAIRE
- Journal :
- Anaesthesia
- Accession number :
- edsair.doi.dedup.....380117d34af1269bbd5a5c07aa86873d