Supplementary Figure S4 from Serologic Profiling Using an Epstein-Barr Virus Mammalian Expression Library Identifies EBNA1 IgA as a Prediagnostic Marker for Nasopharyngeal Carcinoma

IgA detection of select EBV proteins in sera from incident NPC cases and healthy controls in the SCHS and SCS cohorts. Heatmap depicting normalized detection of IgAH against 8 EBV proteins identified in the NPC differential IgA panel (Fig 3) from (A) 20 SCHS pairs from the discovery group or (B) 31 pairs up to 10 years prior to NPC diagnosis from the SCHS and SCS validation groups. All samples were previously tested for EBNA1 IgA and status is shown as positive (+) or negative (-). Fisher’s exact test identifies proteins (bolded) that discriminate case from controls and denoted *p