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Differences in Cytokine Expression and STAT3 Activation between Healthy Controls and Patients of Unexplained Recurrent Spontaneous Abortion (URSA) during Early Pregnancy
- Source :
- PLoS ONE, Vol 11, Iss 9, p e0163252 (2016), PLoS ONE
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- Unexplained recurrent spontaneous abortion (URSA) is a common complication of pregnancy. Although tolerance of the maternal immune system is considered to be essential for a normal pregnancy, the precise mechanism underlying the pathogenesis of URSA remains to be fully elucidated, albeit it is known to involve inflammation. Here, we examine the relationship between the expression of inflammatory cytokines and the activation of downstream signaling pathways in URSA patients. Decidual and peripheral blood samples were collected from 30 URSA patients and from 30 women with normal early pregnancies. Western blot analysis was used to measure the expression levels of signal transducers and activators of transcription 3(STAT3), phosphorylated STAT3(p-STAT3), and interleukin-17 receptor(IL-17R) in the decidual samples. Enzyme-linked immunosorbent assay was used to assess the levels of IL-17, IL-10, IL-6, and IL-23 in the peripheral blood and decidual samples. In the URSA patients, the IL-10 expression levels were lower than those in the control subjects (P
- Subjects :
- 0301 basic medicine
Cell signaling
Physiology
Maternal Health
lcsh:Medicine
Pathogenesis
Signal transduction
Miscarriage
Pathology and Laboratory Medicine
0302 clinical medicine
Pregnancy
Immune Physiology
Medicine and Health Sciences
Medicine
Enzyme-Linked Immunoassays
lcsh:Science
Receptor
Immune Response
Innate Immune System
030219 obstetrics & reproductive medicine
Multidisciplinary
biology
Obstetrics and Gynecology
STAT signaling
Bioassays and Physiological Analysis
Cytokines
medicine.symptom
Research Article
Cell biology
Ursa
Immunology
Inflammation
Research and Analysis Methods
Proinflammatory cytokine
03 medical and health sciences
Signs and Symptoms
Immune system
Diagnostic Medicine
Immunoassays
Enzyme Assays
business.industry
lcsh:R
Biology and Life Sciences
Molecular Development
biology.organism_classification
medicine.disease
Pregnancy Complications
030104 developmental biology
Immune System
Immunologic Techniques
Women's Health
lcsh:Q
Biochemical Analysis
business
Developmental Biology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....37f8e1e0ffdf78661c60d6bcf499d673