Back to Search
Start Over
Identifying adverse drug reactions from free-text electronic hospital health record notes
- Source :
- British Journal of Clinical Pharmacology, 88(3), 1235. NLM (Medline), British Journal of Clinical Pharmacology, 88(3), 1235-1245. Wiley-Blackwell
- Publication Year :
- 2022
-
Abstract
- Background: Adverse drug reactions (ADRs) are estimated to be the fifth cause of hospital death. Up to 50% are potentially preventable and a significant number are recurrent (reADRs). Clinical decision support systems have been used to prevent reADRs using structured reporting concerning the patient's ADR experience, which in current clinical practice is poorly performed. Identifying ADRs directly from free text in electronic health records (EHRs) could circumvent this. Aim: To develop strategies to identify ADRs from free-text notes in electronic hospital health records. Methods: In stage I, the EHRs of 10 patients were reviewed to establish strategies for identifying ADRs. In stage II, complete EHR histories of 45 patients were reviewed for ADRs and compared to the strategies programmed into a rule-based model. ADRs were classified using MedDRA and included in the study if the Naranjo causality score was ≥1. Seriousness was assessed using the European Medicine Agency's important medical event list. Results: In stage I, two main search strategies were identified: keywords indicating an ADR and specific prepositions followed by medication names. In stage II, the EHRs contained a median of 7.4 (range 0.01-18) years of medical history covering over 35 000 notes. A total of 318 unique ADRs were identified of which 63 were potentially serious and 179 (sensitivity 57%) were identified by the rule. The method falsely identified 377 ADRs (positive predictive value 32%). However, it also identified an additional eight ADRs. Conclusion: Two key strategies were developed to identify ADRs from hospital EHRs using free-text notes. The results appear promising and warrant further study.
- Subjects :
- clinical decision support
Drug-Related Side Effects and Adverse Reactions
MedDRA
Drug allergy
adverse drug reaction
Clinical decision support system
medicine
Text messaging
Adverse Drug Reaction Reporting Systems
Electronic Health Records
Humans
Medical history
Pharmacology (medical)
free-text
Drug reaction
natural language processing
adverse drug event
Pharmacology
business.industry
Medical record
text-mining
medicine.disease
Hospitals
clinical decision support system
Medical emergency
Electronics
business
Adverse drug reaction
drug allergy
Subjects
Details
- Language :
- English
- ISSN :
- 03065251
- Volume :
- 88
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- British Journal of Clinical Pharmacology
- Accession number :
- edsair.doi.dedup.....37ee45949ac10b64f8c30563035c2ed4