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Ursodeoxycholic acid after bile duct stone removal and risk factors for recurrence: a randomized trial
- Source :
- Journal of Hepato-Biliary-Pancreatic Sciences. 23:132-136
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Background Currently, no established pharmacologic treatment exists for the prevention of recurrent common bile duct (CBD) stones. Methods Here, we present a multi-center randomized trial that compared the CBD recurrence rate after bile duct stone removal between patients given ursodeoxycholic acid (UDCA) and the untreated group. A total of 36 patients were randomly assigned to either the UDCA (n = 15) or the untreated group (n = 21). The primary end-point was the recurrence rate of CBD stones. Results The recurrence rate of CBD stones was 6.6% in the UDCA group and 18.6% in the untreated group (P = 0.171). A multivariate analysis found that not receiving UDCA was an independent risk factor for stone recurrence. The recurrence rates of CBD stones did not differ by sex, past history of cholecystectomy, or the presence of gallstones. Conclusions Our findings indicate that UDCA may be a novel treatment strategy to prevent the recurrence of CBD stones. However, further evaluation of UDCA in a larger number of subjects will be required to confirm the applicability of these results.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
Untreated group
Gallstones
digestive system
Gastroenterology
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Recurrence
Risk Factors
law
Internal medicine
medicine
Humans
Cholecystectomy
Bile duct stone removal
Risk factor
Aged
Aged, 80 and over
Hepatology
Common bile duct
business.industry
Ursodeoxycholic Acid
Middle Aged
medicine.disease
digestive system diseases
Ursodeoxycholic acid
surgical procedures, operative
medicine.anatomical_structure
030220 oncology & carcinogenesis
Multivariate Analysis
Female
030211 gastroenterology & hepatology
Surgery
business
medicine.drug
Subjects
Details
- ISSN :
- 18686974
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Journal of Hepato-Biliary-Pancreatic Sciences
- Accession number :
- edsair.doi.dedup.....37e57fa644226692b41b21a29326b3fd