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Causal association of circulating cholesterol levels with dementia: a mendelian randomization meta-analysis
- Source :
- Translational Psychiatry, Translational Psychiatry, Vol 10, Iss 1, Pp 1-8 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Prospective studies have shown that abnormally circulating cholesterol is associated with the risk of dementia. However, whether the association is causal or not remains unclear. We attempt to infer the causal association in a MR meta-analysis by using ApoE gene polymorphisms as instrument variables. Studies with dementia risk (27 studies) or circulating lipid levels (7 studies) were included, with totally 3136 dementia patients and 3103 healthy controls. The analyses showed that carriers of ε2 allele significantly were of decreased risk of AD (OR = 0.70; 95% CI: 0.58–0.84; P P P P P P P P
- Subjects :
- 0301 basic medicine
Apolipoprotein E
medicine.medical_specialty
Genotype
Gastroenterology
Article
lcsh:RC321-571
03 medical and health sciences
Cellular and Molecular Neuroscience
chemistry.chemical_compound
0302 clinical medicine
Apolipoproteins E
Internal medicine
Mendelian randomization
medicine
Dementia
Humans
Clinical genetics
Prospective Studies
Allele
Prospective cohort study
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Biological Psychiatry
Alleles
Cholesterol
business.industry
Diagnostic markers
Mendelian Randomization Analysis
medicine.disease
Psychiatry and Mental health
030104 developmental biology
chemistry
Causal association
Meta-analysis
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 21583188
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Translational Psychiatry
- Accession number :
- edsair.doi.dedup.....37da6256261f382e731632b832083170