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Association between low doses of ionizing radiation, administered acutely or chronically, and time to onset of stroke in a rat model
- Source :
- Journal of Radiation Research
- Publication Year :
- 2020
- Publisher :
- Oxford University Press, 2020.
-
Abstract
- Exposure to high-doses of ionizing radiation has been reported to be associated with the risk of stroke. However, risks associated with lower dose exposures remain unclear, and there is little information available for the risk modification according to the dose-rate. There are few studies using animal models which might be able to provide complementary information on this association. In this study, the male stroke-prone spontaneously hypertensive rat (SHRSP) was used as a model animal. The rats were acutely irradiated with doses between 0 and 1.0 Gy or chronically irradiated with a cumulative dose of 0.5 or 1.0 Gy (at a dose rate of 0.05 or 0.1 Gy/day, respectively). The onset time of stroke related symptoms in SHRSP was used as an endpoint for evaluating the effects of low dose and the low dose-rate gamma-ray exposures. With respect to acute exposure, the time to the onset of stroke in the irradiated rats suggested the presence of a threshold around 0.1 Gy. For the low dose-rate chronically exposed, no significant increase in stroke symptom was observed. These findings are novel and demonstrate that the SHRSP system can be used to determine the association between the risk of stroke and radiation exposure with high sensitivity. Moreover, these studies provide important information regarding the association between the low dose and low dose-rate radiation exposure and circulatory diseases, especially stroke.
- Subjects :
- Male
Time Factors
Health, Toxicology and Mutagenesis
Physiology
Kaplan-Meier Estimate
030218 nuclear medicine & medical imaging
Ionizing radiation
03 medical and health sciences
0302 clinical medicine
Spontaneously hypertensive rat
Radiation, Ionizing
Regular Paper
Medicine
Animals
Radiology, Nuclear Medicine and imaging
Irradiation
Time to onset
Stroke
Proportional Hazards Models
Radiation
business.industry
Cumulative dose
Threshold
Low dose
Dose-Response Relationship, Radiation
medicine.disease
Low dose-rate radiation
Disease Models, Animal
Stroke-prone spontaneously hypertensive rat (SHRSP)
030220 oncology & carcinogenesis
Circulatory system
AcademicSubjects/SCI00960
Low dose radiation
business
Subjects
Details
- Language :
- English
- ISSN :
- 13499157 and 04493060
- Volume :
- 61
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Radiation Research
- Accession number :
- edsair.doi.dedup.....37c6e04b309854ca7b76a13a689a510f