Back to Search
Start Over
Establishment and validation of a prediction model for the probability of malignancy in solid solitary pulmonary nodules in northwest China
- Source :
- Journal of Surgical Oncology. 123:1134-1143
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- To construct a prediction model of solitary pulmonary nodules (SPNs), to predict the possibility of malignant SPNs in patients aged 15-85 years in northwest China for clinical diagnostic and therapeutic decision-making.The features of SPNs were assessed by multivariate logistic regression, followed by visualization using a nomogram. Hosmer lemeshow was applied to evaluate the fitting degree of the model. The area under the receiver operating characteristic (ROC) curve was identified to determine the discriminative ability of the model.Lobulation, spiculation, pleural-tag, carcinoembryonic antigen, neuron-specific enolase, and total serum protein were independent predictors of malignant pulmonary nodules (p .05). Lobulation (100 points) scored the highest in the nomogram, and the Hosmer-Lemeshow goodness-of-fit statistic was 0.805 (p .05). The area under curve (AUC) of the modeling and validation groups using logistic regression were 0.859 (95% CI, 0.805-0.903) and 0.823 (95% CI, 0.738-0.890), respectively. Moreover, the AUC of our model was higher than that of the Mayo model, VA model, and Peking University (AUC 0.823 vs. 0.655 vs. 0.603 vs. 0.521).Our prediction model is more suitable for predicting the possibility of malignant SPNs in northwest China, and can be calculated using a nomogram to determine further treatments.
- Subjects :
- Adult
Male
China
medicine.medical_specialty
Lung Neoplasms
Adolescent
Logistic regression
Malignancy
Young Adult
03 medical and health sciences
Hosmer–Lemeshow test
0302 clinical medicine
Carcinoembryonic antigen
Risk Factors
Total serum protein
Biomarkers, Tumor
medicine
Humans
Aged
Aged, 80 and over
Solitary pulmonary nodule
Models, Statistical
Receiver operating characteristic
biology
business.industry
Incidence
Solitary Pulmonary Nodule
General Medicine
Middle Aged
Nomogram
Prognosis
medicine.disease
Nomograms
ROC Curve
Oncology
Area Under Curve
030220 oncology & carcinogenesis
biology.protein
Female
030211 gastroenterology & hepatology
Surgery
Radiology
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 10969098 and 00224790
- Volume :
- 123
- Database :
- OpenAIRE
- Journal :
- Journal of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....37c65ca743b7cf3337befe5637e8590e