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Lyophilized Composite Loaded with Meloxicam-Peppermint oil Nanoemulsion for Periodontal Pain
- Source :
- Polymers, Polymers, Vol 13, Iss 2317, p 2317 (2021), Volume 13, Issue 14
- Publication Year :
- 2021
-
Abstract
- Maintaining oral health helps to prevent periodontal inflammation and pain, which can progress into more detrimental issues if left untreated. Meloxicam (MX) is a commonly used analgesic for periodontal pain, but it can have adverse gastrointestinal effects and poor solubility. Therefore, this study aimed to enhance the solubility of MX by developing a self-nanoemulsifying drug delivery system (SNEDDS). Considering the anti-ulcer activity of peppermint oil (PO), it was added in a mixture with medium-chain triglyceride (MCT) to the MX-loaded SNEDDS formulation (MX-PO-SNEDDS). After optimization, MX-PO-SNEDDS exhibited a PO:MCT ratio of 1.78:1, surfactant mixture HLB value of 14, and MX:oil mix ratio of 1:15, a particle size of 47 ± 3 nm, stability index of 85 ± 4%, ex vivo Jss of 4 ± 0.6 μg/cm2min, and ulcer index of 1 ± 0.25 %. Then, orally flash disintegrating lyophilized composites (MX-SNELCs) were prepared using the optimized MX-PO-SNEDDs. Results reveal that MX-SNELCs had a wetting time of 4 ± 1 s and disintegration time of 3 ± 1 s with a high in vitro MX release of 91% by the end of 60 min. The results of pharmacokinetic studies in human volunteers further demonstrated that, compared to a marketed MX tablets, MX-SNELCs provided a higher Cmax, Tmax, and AUC and a relatively greater bioavailability of 152.97 %. The successfully developed MX-SNELCs were found to be a better alternative than the conventional tablet dosage form, thus indicating their potential for further development in a clinically acceptable strategy for managing periodontal pain.
- Subjects :
- Polymers and Plastics
Analgesic
Cmax
Organic chemistry
02 engineering and technology
Pharmacology
Ulcer index
030226 pharmacology & pharmacy
Dosage form
Article
03 medical and health sciences
0302 clinical medicine
QD241-441
Pharmacokinetics
medicine
lyophilized tablet
meloxicam
Chemistry
General Chemistry
021001 nanoscience & nanotechnology
Bioavailability
self-nano emulsifying
meloxicam self-nano emulsifying lyophilized tablet
Meloxicam
Drug delivery
0210 nano-technology
medicine.drug
Subjects
Details
- ISSN :
- 20734360
- Volume :
- 13
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Polymers
- Accession number :
- edsair.doi.dedup.....37b0d24e19a66cdee611929cd6d17ea7