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Effects of high-dose bisphenol A on the mouse oral mucosa: A possible link with oral cancers
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Bisphenol A (BPA) is an endocrine disrupting chemical able to promote hormone-responsive tumors. The major route of BPA contamination being oral, the aim of the present study was to investigate BPA effects on oral cells. Here, we evaluated the impact of sub-chronic in vivo exposure to BPA and its in vitro effects on neoplastic and non-neoplastic oral cells. We evaluated the oral mucosa of mice chronically exposed to BPA (200 mg/L). The response of keratinocytes (NOK–SI) and Head and Neck (HN) Squamous Cell Carcinoma (SCC), HN12 and HN13 cell lines to BPA was examined. In vivo, BPA accumulated in oral tissues and caused an increase in epithelial proliferative activity. BPA disrupted the function of keratinocytes by altering pro-survival and proliferative pathways and the secretion of cytokines and growth factors. In tumor cells, BPA induced proliferative, invasive, pro-angiogenic, and epigenetic paths. Our data highlight the harmful effects of BPA on oral mucosa and, tumorigenic and non-tumorigenic cells. Additionally, BPA may be a modifier of oral cancer cell behavior by prompting a functional shift to a more aggressive phenotype.
- Subjects :
- endocrine system
010504 meteorology & atmospheric sciences
medicine.drug_class
Health, Toxicology and Mutagenesis
Endocrine Disruptors
010501 environmental sciences
Toxicology
01 natural sciences
Mice
Phenols
In vivo
medicine
Animals
Endocrine system
Benzhydryl Compounds
Oral mucosa
0105 earth and related environmental sciences
Mouth neoplasm
urogenital system
business.industry
Mouth Mucosa
General Medicine
Pollution
In vitro
stomatognathic diseases
medicine.anatomical_structure
Estrogen
Cell culture
Cancer cell
Cancer research
Mouth Neoplasms
CAMUNDONGOS
business
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 02697491
- Volume :
- 286
- Database :
- OpenAIRE
- Journal :
- Environmental Pollution
- Accession number :
- edsair.doi.dedup.....37b08ec7d0a39b71d778a63ce778c18c