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Bistellettazines A−C and Bistellettazole A: New Terpenyl−Pyrrolizidine and Terpenyl−Imidazole Alkaloids from a Southern Australian Marine Sponge, Stelletta sp
- Source :
- Organic Letters. 10:4247-4250
- Publication Year :
- 2008
- Publisher :
- American Chemical Society (ACS), 2008.
-
Abstract
- Four new alkaloids have been isolated during chemical investigations into a southern Australian marine sponge, Stelletta sp. Detailed spectroscopic analysis, supported by chemical degradation and partial synthesis, permitted structure elucidation of bistellettazines A-C ( 1- 3), the first reported examples of terpenyl-pyrrolizidine conjugates, and bistellettazole A ( 4), a unique cyclic terpenyl-imidazole conjugate. The alkaloids 1- 4 feature unprecedented carbon skeletons that are proposed to share a common convergent biosynthetic origin, arising via the biogenic equivalent of a Diels-Alder addition between two hypothetical polyenyl norsesquiterpene precursors.
- Subjects :
- Magnetic Resonance Spectroscopy
biology
Stereochemistry
Organic Chemistry
Australia
Imidazoles
biology.organism_classification
Amides
Biochemistry
Porifera
chemistry.chemical_compound
Sponge
chemistry
Stelletta
Pyrrolizidine
Animals
Imidazole
Organic chemistry
Physical and Theoretical Chemistry
Pyrrolizidine Alkaloids
Chemical decomposition
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....37ad8f3eedb85e9b71f281057c5bec79