Consequences of diagnosing a tumor predisposition syndrome in children with cancer: A literature review

Authors :: Raoul C.M. Hennekam
Johannes H. M. Merks
Floor A. M. Postema
Saskia M. J. Hopman
Amsterdam Neuroscience - Complex Trait Genetics
CCA - Cancer Treatment and Quality of Life
Amsterdam Neuroscience - Cellular & Molecular Mechanisms
Graduate School
APH - Quality of Care
Amsterdam Neuroscience
Paediatric Genetics
Paediatric Oncology
Source :: Pediatric blood & cancer, 65(1):e26718. Wiley-Liss Inc., Pediatric Blood & Cancer, 65(1). Wiley-Liss Inc.
Publication Year :: 2018
Abstract: Up to 8.5% of children with cancer have a genetic cause for their cancer: a tumor predisposition syndrome (TPS). Diagnosing a TPS is of great importance, as it may have major consequences for clinical care. Patients with TPSs require specific monitoring and management. We present an overview of the cancer-related and noncancer-related consequences for the 36 most common TPSs.

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