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P50 inhibitory gating deficit is correlated with the negative symptomatology of schizophrenia
- Source :
- Psychiatry Research. 136:27-34
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- Abnormal sensory gating in schizophrenia has frequently been reported. The strength of central inhibitory pathways was measured using the P50 component of the auditory evoked potential in a conditioning-testing paradigm. The relationships between a relative decrease in P50 amplitude to repeated auditory stimuli and clinical symptoms remain controversial. Using the Positive and Negative Syndrome Scale, we studied the P50 auditory conditioning-testing paradigm in 81 schizophrenic subjects, categorized into subgroups with and without prominent negative symptoms, in comparison with 88 control subjects. We found increased ratios of testing stimuli to conditioning stimuli in both schizophrenic subgroups relative to findings in the control group. In addition, we found significantly increased mean latencies of the P50 responses to conditioning (C) and testing (T) stimuli and significantly increased T/C ratios in the subgroup with negative symptoms compared with the subgroup with non-negative symptoms.
- Subjects :
- Adult
Male
Psychosis
medicine.medical_specialty
Eye Movements
Gating
Electroencephalography
Audiology
Severity of Illness Index
Conditioning, Psychological
Supine Position
medicine
Humans
Evoked potential
Biological Psychiatry
Sensory gating
medicine.diagnostic_test
Positive and Negative Syndrome Scale
Neural Inhibition
medicine.disease
Psychiatry and Mental health
medicine.anatomical_structure
Schizophrenia
Sensation Disorders
Evoked Potentials, Auditory
Female
Auditory Physiology
Psychology
Neuroscience
Subjects
Details
- ISSN :
- 01651781
- Volume :
- 136
- Database :
- OpenAIRE
- Journal :
- Psychiatry Research
- Accession number :
- edsair.doi.dedup.....3796931d98258dda5c73d7bfc2b1e5a5