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Association of <scp>IRF</scp> 4 single‐nucleotide polymorphism rs12203592 with melanoma‐specific survival

Authors :
Anne E. Cust
Sarah V. Ward
David C. Gibbs
Colin B. Begg
Stefano Rosso
P.A. Kanetsky
Li Luo
Nancy E. Thomas
Hoda Anton-Culver
Marianne Berwick
Irene Orlow
Terence Dwyer
Richard P. Gallagher
R. Zanetti
Stephen B. Gruber
Source :
Br J Dermatol
Publication Year :
2020
Publisher :
Oxford University Press (OUP), 2020.

Abstract

We have previously shown that the functional melanoma risk variant rs12203592 in interferon regulatory factor-4 (IRF4) was associated with increased Breslow thickness, an important prognostic indicator for melanoma. In line with this, a recent study found evidence for an association between the minor T allele of this single nucleotide polymorphism (SNP) and melanoma-specific survival in patients from two European hospitals.

Details

ISSN :
13652133 and 00070963
Volume :
183
Database :
OpenAIRE
Journal :
British Journal of Dermatology
Accession number :
edsair.doi.dedup.....3790ae9240f501454db68efb6ff96de5
Full Text :
https://doi.org/10.1111/bjd.18881