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Maternal serum cytokine levels in pregnancies complicated with threatened preterm labour
- Source :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 33(5)
- Publication Year :
- 2017
-
Abstract
- To investigate serum inflammatory markers in singleton gestations complicated with threatened preterm labour (TPL).Pregnant women complicated with TPL (n = 61) were recruited to measure maternal serum levels of a panel of cytokines and C-reactive protein and then compared to controls without TPL, matched for gestational age (n = 64) and term pregnancies in the prodromal phase of labour (PPL) (n = 31). In addition, baseline cytokine levels were compared among cases and controls according to the outcome.Women with TPL displayed higher CRP and white blood counts levels together with lower granulocyte macrophage colony-stimulating factor (GMC-SF) compared to both controls without TPL and to term gestations in the PPL. Also, interleukin 10 (IL-10), IL-6, IL-7, IL-8 and tumour necrosis alpha (TNF-α) levels were found significantly higher in TPL cases as compared to controls without TPL and term women in the PLL. Baseline cytokine levels (except IL-10) were higher among TPL cases who later delivered preterm. TPL cases delivering preterm displayed lower GMC-SF levels as compared to those delivering at term. Multivariate analysis found that gestational age at birth positively correlated with cervical length and inversely with CRP, IL-6 and TNF-α levels (p 0.0001).TPL and preterm birth were related to inflammatory changes in the maternal side that correlate with cervical shortening and the initiation of uterine contractions.
- Subjects :
- 0301 basic medicine
Adult
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Pregnancy Trimester, Third
Inflammation
Gestational Age
03 medical and health sciences
Young Adult
0302 clinical medicine
Endocrinology
Obstetric Labor, Premature
Pregnancy
medicine
Humans
reproductive and urinary physiology
030219 obstetrics & reproductive medicine
Obstetrics
business.industry
Singleton
Interleukin-6
Tumor Necrosis Factor-alpha
Preterm labour
Interleukin-8
Obstetrics and Gynecology
Granulocyte-Macrophage Colony-Stimulating Factor
Interleukin-10
Serum cytokine
030104 developmental biology
Cytokine
C-Reactive Protein
Case-Control Studies
Immunology
Threatened species
Gestation
Cytokines
Female
medicine.symptom
business
Biomarkers
Subjects
Details
- ISSN :
- 14730766
- Volume :
- 33
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Accession number :
- edsair.doi.dedup.....377745b5609c0546419559623154d70a