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The Neglected Liaison: Targeting Cancer Cell Metabolic Reprogramming Modifies the Composition of Non-Malignant Populations of the Tumor Microenvironment
- Source :
- Cancers, Cancers, Vol 13, Iss 5447, p 5447 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Simple Summary Along with cancer cells, tumor mass also contains numerous types of non-malignant cell populations, all together contributing to an organ-like multicellular organization. This review underlines the importance of taking into consideration the effects metabolic drugs used for cancer therapy may exert on the cells of the tumor microenvironment. Abstract Metabolic reprogramming is a well-known hallmark of cancer, whereby the development of drugs that target cancer cell metabolism is gaining momentum. However, when establishing preclinical studies and clinical trials, it is often neglected that a tumor mass is a complex system in which cancer cells coexist and interact with several types of microenvironment populations, including endothelial cells, fibroblasts and immune cells. We are just starting to understand how such populations are affected by the metabolic changes occurring in a transformed cell and little is known about the impact of metabolism-targeting drugs on the non-malignant tumor components. Here we provide a general overview of the links between cancer cell metabolism and tumor microenvironment (TME), particularly focusing on the emerging literature reporting TME-specific effects of metabolic therapies.
- Subjects :
- Cancer Research
Tumorāassociated macrophages
Cancer-associated fibroblast
Metabolic reprogramming
Non malignant
Review
Biology
03 medical and health sciences
0302 clinical medicine
Immune system
medicine
RC254-282
030304 developmental biology
0303 health sciences
Tumor microenvironment
tumor-associated macrophages
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Cancer
medicine.disease
Cancer metabolism
Transformed cell
Oncology
030220 oncology & carcinogenesis
Cancer cell
Cancer research
Cancer-Associated Fibroblasts
cancer-associated fibroblasts
Subjects
Details
- ISSN :
- 20726694
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Cancers
- Accession number :
- edsair.doi.dedup.....375e42d5d0354fca4afe7ab351e5d73f