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Local recurrence after microwave thermosphere ablation of malignant liver tumors: results of a surgical series
- Source :
- Surgery. 163:709-713
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Background Microwave thermosphere ablation is a new treatment modality that creates spherical ablation zones using a single antenna. This study aims to analyze local recurrence associated with this new treatment modality in patients with malignant liver tumors. Methods This is a prospective clinical study of patients who underwent microwave thermosphere ablation of malignant liver tumors between September 2014 and March 2017. Clinical, operative, and oncologic parameters were analyzed using Kaplan-Meier survival and Cox proportional hazards model. Results One hundred patients underwent 301 ablations. Ablations were performed laparoscopically in 87 and open in 13 patients. Pathology included neuroendocrine liver metastasis (n = 115), colorectal liver metastasis (n = 100), hepatocellular cancer (n = 21), and other tumor types (n = 65). Ninety-day morbidity was 7% with one not procedure-related mortality. Median follow-up was 16 months with 65% of patients completing at least 12 months of follow-up. The rate of local tumor recurrence rate per lesion was 6.6% (20/301). Local tumor, new hepatic, and extrahepatic recurrences were detected in 15%, 40%, and 40% of patients, respectively. Local recurrence rate per pathology was 12% for both colorectal liver metastasis (12/100) and other metastatic tumors (8/65). No local recurrence was observed to date in the neuroendocrine liver metastasis and in the limited number of patients with hepatocellular cancers. Tumor size >3 cm and tumor type were independent predictors of local recurrence. Conclusion This is the first study to analyze local recurrence after microwave thermosphere ablation of malignant liver tumors. Short-term local tumor control rate compares favorably with that reported for radiofrequency and other microwave technologies in the literature.
- Subjects :
- Ablation Techniques
Male
medicine.medical_specialty
Carcinoma, Hepatocellular
medicine.medical_treatment
030230 surgery
Neuroendocrine tumors
Metastasis
Cohort Studies
Lesion
03 medical and health sciences
0302 clinical medicine
medicine
Carcinoma
Humans
Microwaves
Survival rate
Aged
Proportional Hazards Models
business.industry
Proportional hazards model
Liver Neoplasms
Middle Aged
Ablation
medicine.disease
Survival Rate
Neuroendocrine Tumors
Treatment Outcome
030220 oncology & carcinogenesis
Female
Surgery
Radiology
Neoplasm Recurrence, Local
medicine.symptom
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 00396060
- Volume :
- 163
- Database :
- OpenAIRE
- Journal :
- Surgery
- Accession number :
- edsair.doi.dedup.....37471d2793af8b7d46974958fc35e79b