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A Notch in Time: Spatiotemporal Analysis of Notch Signaling during Pancreas Development
- Source :
- Developmental cell. 52(6)
- Publication Year :
- 2020
-
Abstract
- Notch signaling is a major regulator of pancreas development, yet how it precisely controls pancreatic cell fates has remained obscure. Seymour et al. (2020) use sophisticated Notch- based genetic tools to uncover highly context- and temporally-specific roles for DLL1, JAG1, and HES1 in regulating pancreatic progenitor cell growth and specification.
- Subjects :
- JAG1
Cellular differentiation
Regulator
Notch signaling pathway
Context (language use)
Biology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Spatio-Temporal Analysis
medicine
HES1
Molecular Biology
Pancreas
030304 developmental biology
0303 health sciences
Receptors, Notch
Cell Differentiation
Cell Biology
Cell biology
medicine.anatomical_structure
Pancreatic progenitor cell
030217 neurology & neurosurgery
Developmental Biology
Signal Transduction
Subjects
Details
- ISSN :
- 18781551
- Volume :
- 52
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Developmental cell
- Accession number :
- edsair.doi.dedup.....37414337df8ffe0f855f5e1b821b4088