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Metabolic profile of women with PCOS in Brazil : a systematic review and meta-analysis
- Source :
- Repositório Institucional da UFRGS, Universidade Federal do Rio Grande do Sul (UFRGS), instacron:UFRGS, Diabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-16 (2021), Diabetology & Metabolic Syndrome
- Publication Year :
- 2021
-
Abstract
- Background Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting women of reproductive age and associated with reproductive and metabolic dysfunction. Few studies are available regarding metabolic traits in Brazilian women with PCOS. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding metabolic traits and comorbidities in Brazilian women with polycystic ovary syndrome (PCOS). Methods We systematically searched PubMed, Cochrane Central Register of Controlled Trials, and Embase for cross-sectional, case–control, or cohort studies focusing on populations of different regions from Brazil, published until July 31, 2019. Studies were selected if they reported PCOS diagnostic criteria. Studies without a control group were included if they presented relevant metabolic data. Results Of 4856 studies initially identified, 27 were included in the systematic review and 12 were included in the meta-analysis, for a total of 995 women with PCOS defined by Rotterdam criteria and 2275 controls from different regions of Brazil. Obesity, metabolic syndrome and IGT were prevalent, and standard mean differences for BMI (SMD 0.67, 95% CI, 0.29, 1.05), waist circumference (SMD 0.22, 95% CI 0.02, 0.41), systolic (SMD 0.66, 95% CI 0.30, 1.01) and diastolic blood pressure (SMD 0.55, 95% CI 0.24, 0.87), glucose (SMD 0.21, 95% CI 0.04, 0.38) and HOMA (SMD 0.78, 95% CI 0.52, 1.04) were significantly higher in Brazilian women with PCOS compared to controls. Lipid profile was more adverse in PCOS vs. non-PCOS women. Between-study heterogeneities were low/moderate for glucose and HOMA and moderate/high for the other variables. Conclusions The data of this systematic review and meta-analysis indicate that Brazilian women with PCOS have a worse metabolic profile than women without PCOS with no important regional differences. The prevalence of metabolic changes is intermediate in Brazil vs. other countries.
- Subjects :
- medicine.medical_specialty
Waist
endocrine system diseases
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Obesity
lcsh:RC620-627
Polycystic ovary syndrome
Metabolismo
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
business.industry
Research
nutritional and metabolic diseases
Síndrome do ovário policístico
medicine.disease
Polycystic ovary
Metabolic abnormalities
lcsh:Nutritional diseases. Deficiency diseases
Mulheres
Revisão sistemática
Meta-analysis
Blood pressure
Metabolic syndrome
Lipid profile
business
Brazil
Cohort study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da UFRGS, Universidade Federal do Rio Grande do Sul (UFRGS), instacron:UFRGS, Diabetology & Metabolic Syndrome, Vol 13, Iss 1, Pp 1-16 (2021), Diabetology & Metabolic Syndrome
- Accession number :
- edsair.doi.dedup.....37408aa5d63fe2f61a29ed331b666751