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Antinociceptive effect and gastroprotective mechanisms of 3,5-diprenyl-4-hydroxyacetophenone from Ageratina pichinchensis
- Source :
- Fitoterapia. 87
- Publication Year :
- 2012
-
Abstract
- The present study aimed to evaluate the antinociceptive activity (in inflammatory and neuropathic pain models) and gastroprotective effect of the 3,5-diprenyl-4-hydroxyacetophenone (HYDP), isolated from Ageratina pichinchensis . The gastroprotective activity of this plant was previously reported by our workgroup, finding encesanescin to be one active compound. The present results show that HYDP reduced nociception in a dose-dependent manner in carrageenan and L5/L6 spinal nerve ligation, with efficacies of 72.6 and 57.1%, respectively, at doses of 100 and 562 mg/kg. HYDP also showed gastroprotective activity in the model of ethanol-induced gastric lesion, with a 75.59% maximum inhibition of ulcers at a dose of 100 mg/kg. This gastroprotective effect was attenuated by N G -nitro- l -arginine methyl ester, indomethacin and N-ethylmaleimide, indicating that NO, prostaglandins and sulfhydryl groups are involved in the mechanisms of action. This is the first evidence, to our knowledge, of the antinociceptive and gastroprotective activities of HYDP.
- Subjects :
- Male
Pharmacology
Carrageenan
Nitric Oxide
chemistry.chemical_compound
Gastrointestinal Agents
Drug Discovery
Medicine
Animals
Ageratina
Stomach Ulcer
Sulfhydryl Compounds
Spinal nerve ligation
Rats, Wistar
Ligation
Inflammation
Analgesics
biology
Dose-Response Relationship, Drug
Ethanol
business.industry
Plant Extracts
Acetophenones
General Medicine
Gastric lesions
biology.organism_classification
Rats
Plant Leaves
Disease Models, Animal
Nociception
Spinal Nerves
chemistry
Active compound
Neuropathic pain
Arginine methyl ester
Prostaglandins
Neuralgia
business
Phytotherapy
Subjects
Details
- ISSN :
- 18736971
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....373a6f9a5515c7a85d16447984c00170