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Bioactive extracts from persimmon waste: influence of extraction conditions and ripeness
- Source :
- Méndez, Daniel Fabra Rovira, María José Falcó Ferrando, Irene Lourdes Sánchez, Gloria Aranaz, Paula Vettorazzi Armental, Ariane López Rubio, Amparo 2021 Bioactive extracts from persimmon waste: influence of extraction conditions and ripeness. Food & Function 12 7428 7439, IRTA Pubpro. Open Digital Archive, Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Digital.CSIC: Repositorio Institucional del CSIC, Consejo Superior de Investigaciones Científicas (CSIC), Dadun. Depósito Académico Digital de la Universidad de Navarra, instname, Digital.CSIC. Repositorio Institucional del CSIC
- Publication Year :
- 2021
- Publisher :
- Royal Society of Chemistry (RSC), 2021.
-
Abstract
- In this work, a bioactive persimmon extract was produced from discarded fruits. A central composite design was used to evaluate the effect of different extraction parameters and ripeness stages of persimmon fruits on the total phenolic content and antioxidant activity of the resulting extracts. Significantly greater phenolic contents were obtained from immature persimmon (IP) fruits. The optimum IP extract with the conditions set by the experimental design was industrially up-scaled and its composition and functional properties were evaluated and compared with those obtained under lab-scale conditions. Both extracts contained significant protein (>20%) and phenolic contents (∼11–27 mg GA/g dry extract) and displayed significant antiviral activity against murine norovirus and hepatitis A virus. Moreover, the extract showed no toxicity and significantly reduced the fat content and the cellular ageing of Caenorhabditis elegans (C. elegans) without affecting the worm development. These effects were mediated by down-regulation of fat-7, suggesting an anti-lipogenic activity of this extract.<br />This work was financially supported by the grant RTI-2018-094268-B-C22 (MCI/AEI/FEDER, EU). Mendez D. A. is supported by the Ministry of Science, Technology and Innovation (Minciencias) of the Colombian Government (783-2017). M. J. Fabra and A. Martinez-Abad are recipients of Ramon y Cajal (RYC-2014-158) and Juan de la Cierva (IJDC-2017-31255), respectively, from the Spanish Ministry of Economy, Industry and Competitiveness. We also appreciate the funding of the CERCA program (Centres de Recerca de Catalunya) of the Generalitat de Catalunya and from the CIEN project “BIOPRO” from CDTI.
- Subjects :
- 0301 basic medicine
Persimmon
663/664
Antioxidant
Central composite design
Food Handling
Extract
medicine.medical_treatment
ved/biology.organism_classification_rank.species
Phenolic content
Ripeness
Antiviral Agents
Antioxidants
Mice
03 medical and health sciences
0404 agricultural biotechnology
Phenols
Antioxidant activity
medicine
Animals
Persimmon extract
Food science
Caenorhabditis elegans
Waste Products
030109 nutrition & dietetics
Plant Extracts
ved/biology
Chemistry
Norovirus
Extraction (chemistry)
Proteins
04 agricultural and veterinary sciences
General Medicine
Diospyros
040401 food science
Virus
Disease Models, Animal
Fruita
Toxicity
Composition (visual arts)
Food Science
Murine norovirus
Subjects
Details
- ISSN :
- 2042650X, 20426496, and 20180942
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Food & Function
- Accession number :
- edsair.doi.dedup.....37382b30583956a90b6d4660dfbb2299