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Reduced circulating endothelial progenitor cells in thromboangiitis obliterans (Buerger's disease)
- Source :
- Vascular medicine (London, England). 18(6)
- Publication Year :
- 2013
-
Abstract
- To determine the role of endothelial progenitor cells (EPCs) in the pathogenesis of thromboangiitis obliterans (TAO), EPC numbers and colony-forming units, migratory function and tubular structure formation in vitro were compared between 13 young male TAO patients and two age-matched healthy control groups: 11 smokers and 12 non-smokers. TAO patients had significantly lower numbers of EPCs and EPC colonies compared to both non-smokers [190 (97.0–229) vs 528 (380–556), p < 0.001 for EPCs and 0.80 (0.53–1.00) vs 2.80 (2.08–4.00) per mm2, p = 0.001 for EPC colonies] and smokers [190 (97.0–229) vs 272 (229–326), p = 0.012 for EPCs and 0.80 (0.53–1.00) vs 2.80 (1.80–3.93) per mm2, p = 0.001 for EPC colonies]. However, there were no significant differences in migratory function or tube formation between the three groups. These results suggest that TAO patients have an intrinsic decrease in EPCs not entirely associated with smoking, which may be the cause of endothelial dysfunction seen in TAO patients leading to the development of this disease at early ages.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endothelial progenitor cell
Pathogenesis
Young Adult
Cell Movement
Internal medicine
Healthy control
medicine
Humans
Endothelial dysfunction
Progenitor cell
Young male
Buerger's disease
Tube formation
business.industry
Stem Cells
Smoking
Endothelial Cells
Thromboangiitis Obliterans
Cell Differentiation
Middle Aged
medicine.disease
Endocrinology
embryonic structures
Immunology
cardiovascular system
Cardiology and Cardiovascular Medicine
business
circulatory and respiratory physiology
Subjects
Details
- ISSN :
- 14770377
- Volume :
- 18
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Vascular medicine (London, England)
- Accession number :
- edsair.doi.dedup.....372847ff07e5a75282d51a9eee7853ba