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Role of Polycomb in the control of transposable elements
- Source :
- Trends in Genetics, Trends in Genetics, Elsevier, 2021, 37 (10), pp.882-889. ⟨10.1016/j.tig.2021.06.003⟩, Trends in Genetics, 2021, 37 (10), pp.882-889. ⟨10.1016/j.tig.2021.06.003⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- It is generally considered that Polycomb Repressive Complex (PRC)2 deposits the histone mark H3K27me3 on silent protein-coding genes, while transposable elements are repressed by DNA and/or H3K9 methylation. Yet, there is increasing evidence that PRC2 also targets and even silences transposable elements in representatives of several distantly related eukaryotic lineages. In plants and animals, H3K27me3 is present on transposable elements in mutants and specific cell types devoid of DNA methylation. In this Opinion, we summarize the experimental evidence for this phenomenon across the eukaryotic kingdom, and discuss its functional and evolutionary significance. We hypothesize that an ancestral role of Polycomb group (PcG) proteins was to silence transposable elements.
- Subjects :
- Transposable element
Heterochromatin
Mutant
Polycomb-Group Proteins
macromolecular substances
Histones
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN]
Genetics
Animals
Humans
Gene
030304 developmental biology
0303 health sciences
biology
Polycomb Repressive Complex 2
DNA Methylation
Histone
chemistry
Evolutionary biology
DNA methylation
DNA Transposable Elements
biology.protein
PRC2
030217 neurology & neurosurgery
DNA
Subjects
Details
- Language :
- English
- ISSN :
- 01689525
- Database :
- OpenAIRE
- Journal :
- Trends in Genetics, Trends in Genetics, Elsevier, 2021, 37 (10), pp.882-889. ⟨10.1016/j.tig.2021.06.003⟩, Trends in Genetics, 2021, 37 (10), pp.882-889. ⟨10.1016/j.tig.2021.06.003⟩
- Accession number :
- edsair.doi.dedup.....3727e03998c3663c1f3e1f87aea343f6