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Signal flow between CWI/TOR and CWI/RAS in budding yeast under conditions of oxidative stress and glucose starvation
- Source :
- Recercat. Dipósit de la Recerca de Catalunya, instname
- Publication Year :
- 2010
- Publisher :
- Informa UK Limited, 2010.
-
Abstract
- The CWI pathway cross-talks with TOR and RAS in both the oxidative and glucose starvation responses. Mtl1 is the cell-wall protein in charge of sensing and regulating this response. Rom2 and Rho1, which are the upper elements in the pathway, mediate this signal. Several outputs are involved and required for this response, one of which, ribosomal gene expression, seems to be regulated by Sfp1, amongst other possible transcription factors. Moreover, cross-talk also occurs in a reverse flow from TOR and RAS to the CWI pathway. Thus Tor1 and Ras2 inhibition also activates Slt2 in the absence of the Mtl1 protein and assures the proper adaptive response to oxidation and glucose deprivation.
- Subjects :
- Starvation
Mtl1
CWI
Oxidative phosphorylation
Biology
medicine.disease_cause
Budding yeast
Hedgehog signaling pathway
RAS2
Article Addendum
Cell biology
Biochemistry
Gene expression
medicine
TOR1
medicine.symptom
Ras2
General Agricultural and Biological Sciences
Transcription factor
Oxidative stress
Subjects
Details
- ISSN :
- 19420889
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Communicative & Integrative Biology
- Accession number :
- edsair.doi.dedup.....37211ab5051d8ade4ec713e182f64646
- Full Text :
- https://doi.org/10.4161/cib.3.6.12974