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Signal flow between CWI/TOR and CWI/RAS in budding yeast under conditions of oxidative stress and glucose starvation

Authors :
Mima I. Petkova
Nuria Pujol-Carrion
Maria Angeles de la Torre-Ruiz
Source :
Recercat. Dipósit de la Recerca de Catalunya, instname
Publication Year :
2010
Publisher :
Informa UK Limited, 2010.

Abstract

The CWI pathway cross-talks with TOR and RAS in both the oxidative and glucose starvation responses. Mtl1 is the cell-wall protein in charge of sensing and regulating this response. Rom2 and Rho1, which are the upper elements in the pathway, mediate this signal. Several outputs are involved and required for this response, one of which, ribosomal gene expression, seems to be regulated by Sfp1, amongst other possible transcription factors. Moreover, cross-talk also occurs in a reverse flow from TOR and RAS to the CWI pathway. Thus Tor1 and Ras2 inhibition also activates Slt2 in the absence of the Mtl1 protein and assures the proper adaptive response to oxidation and glucose deprivation.

Details

ISSN :
19420889
Volume :
3
Database :
OpenAIRE
Journal :
Communicative & Integrative Biology
Accession number :
edsair.doi.dedup.....37211ab5051d8ade4ec713e182f64646
Full Text :
https://doi.org/10.4161/cib.3.6.12974