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Supplementary Methods, Figures 1 - 7 from Hrk Mediates 2-Methoxyestradiol–Induced Mitochondrial Apoptotic Signaling in Prostate Cancer Cells
- Publication Year :
- 2023
- Publisher :
- American Association for Cancer Research (AACR), 2023.
-
Abstract
- PDF file - 321K, Figure S1. Induction of BH3-only protein family members by 2-ME in prostate cancer cells. Figure S2. Hrk knockdown prevents 2-ME-mediated cell death in time-dependent manner. Figure S3. Mitochondrial localization of Hrk. Figure S4. No change in total cell number after 2-ME treatment. Figure S5. Bax is not involved in 2-ME-mediated apoptotic cell death. Figure S6. Endogenous Bak interacts with Bcl-xL but not with Bcl-2 in prostate cancer cells. Figure S7. Hrk requires the BH3 domain for pro-apoptotic function.
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....371f74410197d203944b53322a3e1e43