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Gender but not diabetes, hypertension or smoking affects infarct evolution in ST-elevation myocardial infarction patients – data from the CHILL-MI, MITOCARE and SOCCER trials
- Source :
- BMC Cardiovascular Disorders, Vol 19, Iss 1, Pp 1-10 (2019), Nordlund, D, Engblom, H, Bonnet, J L, Hansen, H S, Atar, D, Erlinge, D, Ekelund, U, Heiberg, E, Carlsson, M & Arheden, H 2019, ' Gender but not diabetes, hypertension or smoking affects infarct evolution in ST-elevation myocardial infarction patients-Data from the CHILL-MI, MITOCARE and SOCCER trials ', BMC Cardiovascular Disorders, vol. 19, no. 1, 161 . https://doi.org/10.1186/s12872-019-1139-7, BMC Cardiovascular Disorders
- Publication Year :
- 2019
- Publisher :
- BMC, 2019.
-
Abstract
- Background Infarct evolution rate and response to acute reperfusion therapy may differ between patients, which is important to consider for accurate management and treatment of patients with ST-elevation myocardial infarction (STEMI). The aim of this study was therefore to investigate the association of infarct size and myocardial salvage with gender, smoking status, presence of diabetes or history of hypertension in a cohort of STEMI-patients. Methods Patients (n = 301) with first-time STEMI from the three recent multi-center trials (CHILL-MI, MITOCARE and SOCCER) underwent cardiac magnetic resonance (CMR) imaging to determine myocardium at risk (MaR) and infarct size (IS). Myocardial salvage index (MSI) was calculated as MSI = 1-IS/MaR. Pain to balloon time, culprit vessel, trial treatments, age, TIMI grade flow and collateral flow by Rentrop grading were included as explanatory variables in the statistical model. Results Women (n = 66) had significantly smaller MaR (mean difference: 5.0 ± 1.5% of left ventricle (LV), p
- Subjects :
- Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Myocardial Reperfusion
030204 cardiovascular system & hematology
Area at risk
Risk Assessment
Culprit
03 medical and health sciences
Sex Factors
0302 clinical medicine
Reperfusion therapy
Risk Factors
Internal medicine
Diabetes mellitus
Diabetes Mellitus
medicine
Humans
Multicenter Studies as Topic
030212 general & internal medicine
Myocardial infarction
cardiovascular diseases
Aged
Randomized Controlled Trials as Topic
Angiology
Tissue Survival
business.industry
Myocardium
Smoking
Diabetes
Gender
Health Status Disparities
Middle Aged
medicine.disease
Cardiac surgery
Treatment Outcome
lcsh:RC666-701
Cohort
Hypertension
Cardiology
ST Elevation Myocardial Infarction
Female
Sex
Cardiology and Cardiovascular Medicine
business
TIMI
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712261
- Volume :
- 19
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cardiovascular Disorders
- Accession number :
- edsair.doi.dedup.....371bdc47634660127530ce11065f2cc7