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Effects of di-n-butyl phthalate on gills- and liver-specific EROD activities and CYP1A levels in juvenile red snapper (Lutjanus argentimaculatus)
- Source :
- Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 232:108757
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Di-n-butyl phthalate, one of the most easily detected pollutants of phthalate esters in the environment, has been added to the priority list of hazardous substances by many countries. As one of low molecular weight phthalates, Di-n-butyl phthalate may have a great adverse potency on various aquatic organisms. In this study, the juvenile red snapper, Lutjanus argentimaculatus, was exposed to the concentrations of Di-n-butyl phthalate (20 μg L−1, 100 μg L−1 and 500 μg L−1) for 15 days. EROD activities and CYP1A levels were measured in liver and gill tissues. In gills, the similar effect has been found to inhibit or induce EROD activities and CYP1A levels, and there existed a good correlation between them. Whereas in the case of the liver, a moderate correlation was observed between EROD activities and CYP1A levels, which was mainly due to the inhibited EROD activities and the CYP1A levels with no significant difference by day 15. In conclusion, this study revealed the similar and different effects of cytochrome P450 enzymes on fish in the time-, concentration-, and tissue-dependent Di-n-butyl phthalate exposure. Furthermore, as the adverse effects indicated between CYP1A levels and EROD activities, metabolic mechanisms of phthalates in different tissues should be highly emphasized in future studies.
- Subjects :
- Gills
Gill
animal structures
Physiology
Health, Toxicology and Mutagenesis
010501 environmental sciences
Toxicology
01 natural sciences
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
Plasticizers
Cytochrome P-450 CYP1A1
Animals
Potency
Juvenile
Food science
030304 developmental biology
0105 earth and related environmental sciences
Pollutant
chemistry.chemical_classification
0303 health sciences
biology
Chemistry
Fishes
Phthalate
Cytochrome P450
Cell Biology
General Medicine
biology.organism_classification
Dibutyl Phthalate
Lutjanus
Enzyme
Liver
biology.protein
Water Pollutants, Chemical
Subjects
Details
- ISSN :
- 15320456
- Volume :
- 232
- Database :
- OpenAIRE
- Journal :
- Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology
- Accession number :
- edsair.doi.dedup.....370f44767b7e7d692c0466c29e9ccd20