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The mucosal immune system of fish: the evolution of tolerating commensals while fighting pathogens
- Source :
- Fishshellfish immunology. 35(6)
- Publication Year :
- 2013
-
Abstract
- The field of mucosal immunology research has grown fast over the past few years, and our understanding on how mucosal surfaces respond to complex antigenic cocktails is expanding tremendously. With the advent of new molecular sequencing techniques, it is easier to understand how the immune system of vertebrates is, to a great extent, orchestrated by the complex microbial communities that live in symbiosis with their hosts. The commensal microbiota is now seen as the “extended self” by many scientists. Similarly, fish immunologist are devoting important research efforts to the field of mucosal immunity and commensals. Recent breakthroughs on our understanding of mucosal immune responses in teleost fish open up the potential of teleosts as animal research models for the study of human mucosal diseases. Additionally, this new knowledge places immunologists in a better position to specifically target the fish mucosal immune system while rationally designing mucosal vaccines and other immunotherapies. In this review, an updated view on how teleost skin, gills and gut immune cells and molecules, function in response to pathogens and commensals is provided. Finally, some of the future avenues that the field of fish mucosal immunity may follow in the next years are highlighted.
- Subjects :
- Mammals
Vaccines
Mucosal Immune Responses
Probiotics
Fishes
General Medicine
Aquatic Science
Biology
Commensalism
Biological Evolution
Article
Evolution, Molecular
Important research
Immune system
Mucosal immunology
Antigen
Immunology
Environmental Chemistry
Fish
Animals
Mucosal immunity
Immunity, Mucosal
Subjects
Details
- ISSN :
- 10959947
- Volume :
- 35
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Fishshellfish immunology
- Accession number :
- edsair.doi.dedup.....36ff49ec3ba9ca1c1f0e4c6588041f45