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Saliva cortisol, melatonin levels and circadian rhythm alterations in Chinese primary school children with dyslexia
- Source :
- Medicine
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Cortisol is the main end product of hypothalamic-pituitary-adrenal gland (HPA axis), and melatonin (MT) has a regulating effect on HPA axis, and both are closely related to individual behavior and cognitive function. We aimed to evaluate cortisol and MT roles on children dyslexia in this study. A total of 72 dyslexic children and 72 controls were recruited in this study. Saliva samples were collected in the morning, afternoon, and night, respectively. The levels of saliva cortisol and MT were measured by enzyme-linked immunosorbent assay method. Differences of cortisol and MT levels between dyslexic and normal children were compared, and the variation trend was also analyzed by dynamic monitoring in 3 time points. The levels of salivary cortisol and MT in children with dyslexia were all lower than those in normal children whether in the morning (7:30-8:30 am ), at afternoon (15:30-16:30 pm ) or at night (21:30-22:30 pm ) (all P
- Subjects :
- Male
circadian rhythm
China
endocrine system
medicine.medical_specialty
Saliva
Hydrocortisone
Observational Study
melatonin
cortisol
Chronobiology Disorders
Dyslexia
Melatonin
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
risk factors
030212 general & internal medicine
Circadian rhythm
Child
Salivary cortisol
Morning
business.industry
Case-control study
General Medicine
medicine.disease
Endocrinology
Case-Control Studies
030220 oncology & carcinogenesis
Normal children
Female
business
hormones, hormone substitutes, and hormone antagonists
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 15365964 and 00257974
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.doi.dedup.....36f53ff3ad738378880daab0a6d487a2