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Differential effects of the ApoE4 genotype on brain structure and function
- Source :
- NeuroImage, 89, pp. 81-91, NeuroImage, 89, 81-91
- Publication Year :
- 2014
-
Abstract
- Item does not contain fulltext The apolipoprotein E epsilon4 allele is a well established genetic risk factor for sporadic Alzheimer's disease. It is associated with structural and functional brain changes in healthy young, middle-aged and elderly subjects. In the current study, we assessed the impact of the ApoE genotype on brain macro- and microstructure, cognitive functioning and brain activity in fifty healthy young subjects (25 ApoE epsilon4 (epsilon4+) carriers and 25 non-carriers (epsilon4-), mean age 26.4+/-4.6years). We used diffusion tensor imaging (DTI) and voxel based morphometry (VBM) to assess brain structure, an extensive neuropsychological battery to test cognitive functioning and event-related functional magnetic resonance imaging (fMRI) to capture brain activity during episodic memory encoding and retrieval. ApoE epsilon4 carriers differed from non-carriers in fMRI activations but not in cognitive performance nor in brain micro- and macrostructure. These results suggest functional alterations in the episodic memory network that are modulated by the epsilon4 allele and might precede clinical or structural neurodegeneration.
- Subjects :
- Apolipoprotein E
Adult
Male
Genotype
Brain activity and meditation
Cognitive Neuroscience
Memory, Episodic
Apolipoprotein E4
Brain Structure and Function
Neuropsychological Tests
behavioral disciplines and activities
Young Adult
mental disorders
medicine
Humans
Effects of sleep deprivation on cognitive performance
Episodic memory
Brain Mapping
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
Resting state fMRI
medicine.diagnostic_test
Brain
Voxel-based morphometry
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Neurology
Female
lipids (amino acids, peptides, and proteins)
Psychology
Functional magnetic resonance imaging
Neuroscience
Subjects
Details
- ISSN :
- 10538119
- Database :
- OpenAIRE
- Journal :
- NeuroImage, 89, pp. 81-91, NeuroImage, 89, 81-91
- Accession number :
- edsair.doi.dedup.....36f3e6b282e48b0f0b34b08ddeacd44f