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Evaluation of acute toxicity of triazophos and deltamethrin and their inhibitory effect on AChE activity in Channa punctatus
- Source :
- Toxicology Reports, Vol 5, Iss, Pp 85-89 (2018), Toxicology Reports
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Graphical abstract<br />Highlights • The pesticides have adverse effect on the health of aquatic biota including fishes. • Comparative acute toxicity of both pesticides was determined in the present study. • Both pesticides have affected the behavioural activities of C. punctatus. • Alteration of behavioural patterns may be due to strong inhibition of AChE activity. • Triazophos (organophosphate) is more neurotoxic than deltamethrin (pyrethroid).<br />Pesticides are applied to control the pests indoor and outdoor; however, their remarkable amount reaches to the aquatic system through various routes like run-off, leaching, spray-drift, effluent from factories. These are reported to have negative metabolic impact on different non-target aquatic organisms like fishes. Thus, present study is aimed to evaluate the acute toxicity of two groups of pesticides, organophosphate and pyrethroid, namely triazophos and deltamethrin, respectively. The test was conducted for 96 h period in a freshwater teleost, Channa punctatus. The LC50 values for triazophos and deltamethrin after 96 h treatment was found to be 0.069 mg/L and 7.33 μg/L. The deltamethrin was found to be about ten times more toxic than triazophos to the fish. In treated fish, alterations in various behavioural patterns were observed with increasing concentrations of both the pesticides as compared to control. Further, tissue specific as well as dose dependent inhibition in the acetylcholinesterase (AChE, EC 3.1.1.7) activity was found in brain, muscle and gills in Channa punctatus exposed to both the insecticides. However, the effect was more pronounced in triazophos treated fishes than the deltamethrin. A futuristic approach on biochemical and molecular studies may throw light on the mechanism of action of these pesticides.
- Subjects :
- 0301 basic medicine
Gill
Veterinary medicine
Aché
Health, Toxicology and Mutagenesis
Behavioural pattern
010501 environmental sciences
Biology
Toxicology
01 natural sciences
Article
03 medical and health sciences
chemistry.chemical_compound
lcsh:RA1190-1270
parasitic diseases
0105 earth and related environmental sciences
ComputingMethodologies_COMPUTERGRAPHICS
lcsh:Toxicology. Poisons
Pyrethroid
Organophosphate
Pesticide
Acetylcholinesterase
Acute toxicity
language.human_language
LC50
030104 developmental biology
Deltamethrin
chemistry
Triazophos
Channa punctatus
language
AChE
Subjects
Details
- Language :
- English
- ISSN :
- 22147500
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Toxicology Reports
- Accession number :
- edsair.doi.dedup.....36eeb24ea2fbe1a720ad6b577dad5e8d