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Ginseng berry extract increases nitric oxide level in vascular endothelial cells and improves cGMP expression and blood circulation in muscle cells
- Source :
- Journal of Exercise Nutrition & Biochemistry
- Publication Year :
- 2018
-
Abstract
- [Purpose] The purpose of this study was to determine whether ginseng berry extract improves blood circulation by regulating vasodilator expression in exposed to tumor necrosis factor alpha (TNF-α)-exposed endothelial cells and muscle cells. [Methods] Nitric oxide (NO) and cGMP levels in human umbilical vein endothelial cells (HUVECs) and A7r5 cells exposed to ginseng berry extract were investigated. Based on the in vitro results, healthy participants were treated with ginseng berry extract for 4 weeks and then a non-invasive vascular screening device was used to confirm the improvement of blood circulation. [Results] When TNF-α-treated cells were exposed to the ginseng berry extract, the expression levels of endothelial nitric oxide synthase (eNOS), NO, and cGMP were recovered to almost normal levels. In addition, TNF-ɑ-induced overexpression of vascular cell adhesion molecule 1 (VCAM-1), intracellular adhesion molecule 1 (ICAM-1), e-selectin, and p-selectin was lowered by ginseng berry extract. The ginseng berry extract significantly increased ankle brachial pressure index compared to placebo (p < 0.05). [Conclusion] This study confirmed that the intake of ginseng berry extract improved blood circulation and therefore, its intake would be helpful for people having problems with blood circulation.
- Subjects :
- 0301 basic medicine
cGMP expression
Vasodilation
030204 cardiovascular system & hematology
Pharmacology
complex mixtures
Umbilical vein
Nitric oxide
03 medical and health sciences
chemistry.chemical_compound
Ginseng
0302 clinical medicine
Enos
nitric oxide
Myocyte
blood circulation
biology
Chemistry
Cell adhesion molecule
food and beverages
General Medicine
Original Articles
biology.organism_classification
030104 developmental biology
Tumor necrosis factor alpha
ginseng berry extract
Subjects
Details
- ISSN :
- 22336834
- Volume :
- 22
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of exercise nutritionbiochemistry
- Accession number :
- edsair.doi.dedup.....36ee0b63ad2ece135873de38f40e3a39