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Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case
- Source :
- The American Journal of dermatopathology. 28(4)
- Publication Year :
- 2006
-
Abstract
- Phosphatidylcholine, a lecithin extracted from soy beans, is able to lower serum cholesterol to some extent. When applied intralesionally within fat tissues, it is supposed to act as a "fat burner" and reduce undesired fat deposits. We applied intralesionally phosphatidylcholine within a lipoma of a young patient. To evaluate the volume of the lipoma sonographic imaging was performed before treatment and one month after the third application. Only a partial reduction of the lipoma could be achieved, and increased echographic density could be observed after the third intralesional application of phosphatidylcholine. Surgical excision was performed. Histologic examination showed focal fibrosis, inflammatory reaction with granulomatous features, and presence of pseudomembranous degeneration of fat tissue. Off-label intralesional use of phosphatidylcholine as "fat burner" for the reduction of aesthetically disturbing lipomas should be considered only on a case-to-case basis after careful consideration of possible undesired effects similar to those described in our patient.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
food.ingredient
Adipose tissue
Dermatology
Lecithin
Pathology and Forensic Medicine
chemistry.chemical_compound
food
Fibrosis
Phosphatidylcholine
medicine
Humans
Ultrasonography
business.industry
Histology
Anatomical pathology
General Medicine
Lipoma
medicine.disease
chemistry
Phosphatidylcholines
Histopathology
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 01931091
- Volume :
- 28
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The American Journal of dermatopathology
- Accession number :
- edsair.doi.dedup.....36ecd51e8d67a56eb1d8432608a21d65