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Long-term outcomes and prognostic factor analysis of resected Siewert type II adenocarcinoma of esophagogastric junction in China: a seven-year study
- Source :
- BMC Surgery, BMC Surgery, Vol 20, Iss 1, Pp 1-7 (2020)
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Background The incidence rate of adenocarcinoma of the esophagogastric junction (AEG) has significantly increased over the past two decades. Surgery remains the only curative treatment. However, there are currently few studies on Chinese AEG patients. The purpose of this study was to retrospectively analyze the survival and prognostic factors of AEG patients in our center. Methods Between January 2008 and September 2014, 249 AEG patients who underwent radical resection were enrolled in this retrospective study, including 196 males and 53 females, with a median age of 64 (range 31–82). Prognostic factors were assessed with the log-rank test and Cox univariate and multivariate analyses. Results The 5-year survival rate of all patients was 49%. The median survival time of all enrolled patients was 70.1 months. Pathological type, intraoperative blood transfusion, tumor size, adjuvant chemotherapy, duration of hospital stay, serum CA199, CA125, CA242 and CEA, pTNM stage, lymphovascular or perineural invasion, and the ratio of positive to negative lymph nodes (PNLNR) were significantly associated with overall survival when analyzed in univariate analysis. Conclusions Our study found that adjuvant chemotherapy, PNLNR, intraoperative blood transfusion, tumor size, perineural invasion, serum CEA, and duration of hospital stay after surgery had significance in multivariate analysis and were independent risk factors for survival.
- Subjects :
- Adult
Male
China
medicine.medical_specialty
Multivariate analysis
Blood transfusion
Esophageal Neoplasms
medicine.medical_treatment
lcsh:Surgery
Perineural invasion
Adenocarcinoma
Gastroenterology
Siewert classification
03 medical and health sciences
0302 clinical medicine
Gastrectomy
Esophagogastric junction adenocarcinoma
Internal medicine
medicine
Humans
Lymph nodes
Pathological
Survival rate
Aged
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
Univariate analysis
business.industry
Retrospective cohort study
lcsh:RD1-811
General Medicine
Middle Aged
Prognosis
medicine.disease
Surgery
Survival Rate
Treatment Outcome
030220 oncology & carcinogenesis
Female
030211 gastroenterology & hepatology
Esophagogastric Junction
business
Research Article
Subjects
Details
- ISSN :
- 14712482
- Volume :
- 20
- Database :
- OpenAIRE
- Journal :
- BMC Surgery
- Accession number :
- edsair.doi.dedup.....36e811cf41fc6b1229230c99ee7d471b