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Effects of co-exposure to atrazine and ethanol on the oxidative damage of kidney and liver in Wistar rats
- Source :
- Renal Failure
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Both ethanol (EtoH) and atrazine (ATZ) have hepatic and nephro-toxic effects in rats. In the present study, the toxicity of EtoH (5 g kg−1) on the kidney and liver in the absence or in the presence of different doses of ATZ (50, 100, 300 mg kg−1) was evaluated after 21 days in rats. Results showed that the mixture effects on catalase and superoxide dismutase activities were more severe in both tissues compared to EtoH alone, especially as the dose of ATZ was increased. Hepatic malondialdehyde level (an index of lipid peroxidation) was increased from 20.32% in the EtoH +50 mg kg−1 ATZ-treated rats to 34% in the EtoH +300 mg kg−1 ATZ-treated rats compared to the EtoH values. Renal malondialdehyde values remain as high as 81% in the EtoH-treated rats and the different combine exposure groups. Furthermore, as the dose of ATZ in the mixture was increased, serum uric acid level increased compared to the EtoH values. When the EtoH +300 mg kg−1 ATZ-animals were pretreated with curcumin (an antioxidant), the histopathological changes and peroxidative damages in both tissues were blocked. The exposure of EtoH-treated rats to ATZ enhanced renal and hepatic peroxidative damages in rats.
- Subjects :
- Male
0301 basic medicine
Antioxidant
medicine.medical_treatment
010501 environmental sciences
Critical Care and Intensive Care Medicine
01 natural sciences
Antioxidants
Lipid peroxidation
chemistry.chemical_compound
Laboratory Study
reproductive and urinary physiology
Kidney
biology
Alcoholic Beverages
General Medicine
Catalase
Malondialdehyde
medicine.anatomical_structure
Biochemistry
Nephrology
Toxicity
Atrazine
Oxidation-Reduction
malondialdehyde
histopathological damage
kidney
endocrine system
medicine.medical_specialty
Curcumin
liver
Superoxide dismutase
03 medical and health sciences
Internal medicine
mental disorders
medicine
Animals
Rats, Wistar
0105 earth and related environmental sciences
Ethanol
Herbicides
Superoxide Dismutase
business.industry
Rats
Uric Acid
Oxidative Stress
030104 developmental biology
Endocrinology
chemistry
biology.protein
Lipid Peroxidation
business
Subjects
Details
- ISSN :
- 15256049 and 0886022X
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Renal Failure
- Accession number :
- edsair.doi.dedup.....36e249c9916e04adcd475ecbb9aec67b