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Incidence of hepatitis B viraemia, detected using the polymerase chain reaction, after successful therapy of hepatitis B virus carriers with interferon–α
- Source :
- Journal of Medical Virology. 34:114-118
- Publication Year :
- 1991
- Publisher :
- Wiley, 1991.
-
Abstract
- Thirty-nine patients (62 sera) who, after interferon-alpha therapy for chronic hepatitis B virus (HBV) infection, were seronegative for HBeAg and HBV-DNA by dot blot hybridisation, were tested using the polymerase chain reaction (PCR) for residual viraemia. Overall, 59% of the HBsAg-positive sera and 43% of the HBsAg-negative sera were positive by PCR. All except one of the HBsAg-negative patients had seroconverted to anti-HBs. Between 13 and 18 months after therapy, 33% of the HBsAg-positive and 20% of the HBsAg-negative patients remained viraemic. Eighteen months after the end of treatment, no patient tested was positive. Twenty-three patients were tested sequentially over periods from 1 to 43 months: Thirteen lost HBV-DNA by PCR, three remained positive, five remained negative, and two patients relapsed. The merits and disadvantages of PCR for assessing interferon treatment of HBV carriers are discussed.
- Subjects :
- Time Factors
Molecular Sequence Data
Alpha interferon
medicine.disease_cause
Polymerase Chain Reaction
Virus
Virology
medicine
Humans
Viremia
Hepatitis B Antibodies
Seroconversion
Interferon alfa
Hepatitis B virus
Hepatitis B Surface Antigens
Base Sequence
biology
business.industry
virus diseases
Hepatitis B
medicine.disease
biology.organism_classification
Recombinant Proteins
digestive system diseases
Blotting, Southern
Infectious Diseases
HBeAg
Hepadnaviridae
Carrier State
DNA, Viral
Interferon Type I
business
medicine.drug
Subjects
Details
- ISSN :
- 10969071 and 01466615
- Volume :
- 34
- Database :
- OpenAIRE
- Journal :
- Journal of Medical Virology
- Accession number :
- edsair.doi.dedup.....36e18a5fed31aecdd77b14b3bbd38ed0