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Genetic relatedness and pathogenicity of equine herpesvirus 1 isolated from onager, zebra and gazelle
- Source :
- Archives of virology. 152(2)
- Publication Year :
- 2006
-
Abstract
- Equine herpesvirus 1 was isolated from an onager in 1985, a zebra in 1986 and a Thomson's gazelle in 1996 in USA. The genetic relatedness and pathogenicity of these three viruses were investigated based on the nucleotide sequences of the glycoprotein G (gG) gene, experimental infection in hamsters, and comparison with horse isolates. The gG gene sequences of EHV-1 from onager and zebra were identical. The gG gene sequences of the gazelle isolate showed 99.5% identity to those of onager and zebra isolates. The gG gene sequences of EHV-1 isolated from horses were 99.9-100% identical and 98, 98 and 97.8% similar to gG from onager, zebra and gazelle isolates, respectively. Hamsters inoculated with onager, zebra and gazelle isolates had severe weight loss, compared with hamsters inoculated with horse isolates. The histopathological findings were related to the virulence of each isolate. The results indicated that EHV-1 isolates from onager, zebra and gazelle differ from horse EHV-1 and are much more virulent in hamsters.
- Subjects :
- Male
Genes, Viral
Equine herpesvirus 1
Molecular Sequence Data
Virulence
Virus
Cell Line
Phylogenetics
Virology
Cricetinae
Sequence Homology, Nucleic Acid
Weight Loss
Animals
Amino Acid Sequence
Gene
Phylogeny
biology
Base Sequence
Mesocricetus
Sequence Homology, Amino Acid
Horse
Brain
General Medicine
Nucleic acid amplification technique
Equidae
Herpesviridae Infections
biology.organism_classification
Immunohistochemistry
Disease Models, Animal
nervous system
DNA, Viral
Nucleic Acid Amplification Techniques
Herpesvirus 1, Equid
Subjects
Details
- ISSN :
- 03048608
- Volume :
- 152
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Archives of virology
- Accession number :
- edsair.doi.dedup.....36df5244c50df3957848f4f634be17bc