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Heart Rate Variability in Insulo-Opercular Epilepsy
- Source :
- Brain Sciences, Vol 11, Iss 1505, p 1505 (2021), Brain Sciences, Volume 11, Issue 11
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Background: We aimed to evaluate heart rate variability (HRV) changes in insulo-opercular epilepsy (IOE) and after insulo-opercular surgery. Methods: We analyzed 5-min resting HRV of IOE patients before and after surgery. Patients’ SUDEP-7 risk inventory scores were also calculated. Results were compared with age- and sex-matched patients with temporal lobe epilepsy (TLE) and healthy individuals. Results: There were no differences in HRV measurements between IOE, TLE, and healthy control groups (and within each IOE group and TLE group) in preoperative and postoperative periods. In IOE patients, the SUDEP-7 score was positively correlated with pNN50 (percentage of successive RR intervals that differ by more than 50 ms) (p = 0.008) and RMSSD (root mean square of successive RR interval differences) (p = 0.019). We stratified IOE patients into those whose preoperative RMSSD values were below (Group 1a = 7) versus above (Group 1b = 9) a cut-off threshold of 31 ms (median value of a healthy population from a previous study). In group 1a, all HRV values significantly increased after surgery. In group 1b, time-domain parameters significantly decreased postoperatively. Conclusions: Our results suggest that in IOE, HRV may be either decreased in parasympathetic tone or increased globally in both sympathetic and parasympathetic tones. We found no evidence that insulo-opercular surgeries lead to major autonomic dysfunction when a good seizure outcome is reached. The increase in parasympathetic tone observed preoperatively may be of clinical concern, as it was positively correlated with the SUDEP-7 score.
- Subjects :
- medicine.medical_specialty
insulo-opercular epilepsy
RR interval
Neurosciences. Biological psychiatry. Neuropsychiatry
Article
Temporal lobe
03 medical and health sciences
Epilepsy
0302 clinical medicine
Internal medicine
Healthy control
medicine
Heart rate variability
030212 general & internal medicine
Opercular Epilepsy
business.industry
General Neuroscience
Healthy population
heart rate variability
Seizure outcome
medicine.disease
Cardiology
business
cardiac autonomic dysfunction
030217 neurology & neurosurgery
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 20763425
- Volume :
- 11
- Issue :
- 1505
- Database :
- OpenAIRE
- Journal :
- Brain Sciences
- Accession number :
- edsair.doi.dedup.....36ddf1904b33eadfced23362627cdd33