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Identification of a novel class of annexin genes
- Source :
- FEBS Letters. (1-3):79-86
- Publisher :
- Federation of European Biochemical Societies. Published by Elsevier B.V.
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Abstract
- The annexins are a family of calcium- and phospholipid-binding proteins that have been widely studied in animals. Investigation of annexins in the fungus Aspergillus fumigatus identified a novel annexin-like gene (ANXC4) as well as two conventional annexins (ANXC3.1 and ANXC3.2). The genes were initially identified by bioinformatics, and sequences were then determined experimentally. Reverse transcription polymerase chain reaction indicated that all three genes were expressed. ANXC4 lacked calcium-binding consensus sequences and had a 553 residue N-terminal tail. However, bioinformatics indicated that ANXC4 is an annexin and homologues were identified in other filamentous fungi. ANXC4 therefore represents a new grouping within the annexin family.
- Subjects :
- Annexins
Duplication
Molecular Sequence Data
Biophysics
Sequence alignment
Annexin
Biology
Biochemistry
Aspergillus fumigatus
Fungal Proteins
Structural Biology
Gene duplication
Genetics
Consensus sequence
Animals
Amino Acid Sequence
Molecular Biology
Gene
Peptide sequence
Phylogeny
Base Sequence
Pathogen
Computational Biology
Cell Biology
biology.organism_classification
Reverse transcription polymerase chain reaction
Calcium
Databases, Nucleic Acid
Sequence Alignment
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Issue :
- 1-3
- Database :
- OpenAIRE
- Journal :
- FEBS Letters
- Accession number :
- edsair.doi.dedup.....36c4cef727a82e7265bf1f9a35066ac3
- Full Text :
- https://doi.org/10.1016/S0014-5793(04)00186-3