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Predicting Adverse Outcomes for Shiga Toxin-Producing Escherichia coli Infections in Emergency Departments
- Source :
- J Pediatr, Paediatrics Publications
- Publication Year :
- 2020
-
Abstract
- Objective: To assess the performance of a hemolytic uremic syndrome (HUS) severity score among children with Shiga toxin-producing Escherichia coli (STEC) infections and HUS by stratifying them according to their risk of adverse events. The score has not been previously evaluated in a North American acute care setting. Study design: We reviewed medical records of children 13 were designated as high-risk. We assessed score performance to predict severe adverse events (ie, dialysis, neurologic complication, respiratory failure, and death) using discrimination and net benefit (ie, threshold probability), with subgroup analyses by age and day-of-illness. Results: A total of 167 children had HUS, of whom 92.8% (155/167) had relevant data to calculate the score; 60.6% (94/155) experienced a severe adverse event. Discrimination was acceptable overall (area under the curve 0.71, 95% CI 0.63-0.79) and better among children 26%. Conclusions: The HUS severity score was able to discriminate between high- and low-risk children
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Adverse outcomes
medicine.medical_treatment
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Article
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Internal medicine
Acute care
Clinical Decision Rules
medicine
Humans
030212 general & internal medicine
10. No inequality
Adverse effect
Child
Shiga toxin-producing Escherichia coli
Dialysis
Escherichia coli Infections
Retrospective Studies
Shiga-Toxigenic Escherichia coli
business.industry
Medical record
prognostic index
Area under the curve
Infant, Newborn
Infant
stx1
stx2
Prognosis
3. Good health
Respiratory failure
Child, Preschool
Pediatrics, Perinatology and Child Health
Hemolytic-Uremic Syndrome
North America
hemolytic uremic syndrome
Female
business
Emergency Service, Hospital
Subjects
Details
- ISSN :
- 10976833
- Volume :
- 232
- Database :
- OpenAIRE
- Journal :
- The Journal of pediatrics
- Accession number :
- edsair.doi.dedup.....36bb5bd4dd0e1f789160b95f276a9152