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Characterization of antibody response in patients with acute and chronic chikungunya virus disease
- Source :
- Journal of Clinical Virology, 117, 68-72. Elsevier
- Publication Year :
- 2018
-
Abstract
- Background Chikungunya virus (CHIKV) is a re-emerging arbovirus capable of causing chronic arthralgia, which can last for months to years. Although neutralizing antibodies have been shown to be important for viral clearance, is it not clear whether the quantitative and qualitative nature of antibodies play a role in progression to chronic disease. Objectives To characterize and compare the antibody responses in acute and chronic patients in a prospective observational CHIKV study in Curacao during the 2014-2015 outbreak. Study design We performed virus neutralization tests and ELISA on plasma samples collected from a prospective observational chikungunya study in Curacao to compare the complement-dependent and –independent neutralization capacity, as well as the antibody avidity index of acute and chronic patients. Results We found that there was no significant difference in the virus neutralization titers between patients with acute and chronic chikungunya infection. Furthermore, we found that complement increased the neutralization capacity when large amounts of virus was used. Moreover, we found that patients with acute chikungunya disease had a significantly higher antibody avidity index compared to those with chronic disease. Conclusions This study suggests that virus neutralization titers in late convalescent sera do not play a role in chronic chikungunya. However, the median antibody avidity was lower in these patients and may therefore suggest a role for antibody avidity in the development of chronic disease.
- Subjects :
- 0301 basic medicine
viruses
030106 microbiology
Antibody Affinity
medicine.disease_cause
Antibodies, Viral
Arbovirus
Neutralization
Virus
Disease Outbreaks
03 medical and health sciences
0302 clinical medicine
Neutralization Tests
Virology
Chlorocebus aethiops
Medicine
Animals
Humans
Avidity
030212 general & internal medicine
Chikungunya
Prospective Studies
Neutralizing antibody
Vero Cells
biology
business.industry
virus diseases
Outbreak
Curacao
Complement System Proteins
medicine.disease
Antibodies, Neutralizing
Arthralgia
Infectious Diseases
Immunology
biology.protein
Disease Progression
Chikungunya Fever
Antibody
business
Chikungunya virus
Subjects
Details
- ISSN :
- 18735967 and 13866532
- Volume :
- 117
- Database :
- OpenAIRE
- Journal :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
- Accession number :
- edsair.doi.dedup.....3699a8a151551a2cfbfec9854eab410e