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Uncertainties in synthetic DNA-based data storage
Uncertainties in synthetic DNA-based data storage
- Source :
- Nucleic Acids Research
- Publication Year :
- 2021
- Publisher :
- Oxford University Press (OUP), 2021.
-
Abstract
- Deoxyribonucleic acid (DNA) has evolved to be a naturally selected, robust biomacromolecule for gene information storage, and biological evolution and various diseases can find their origin in uncertainties in DNA-related processes (e.g. replication and expression). Recently, synthetic DNA has emerged as a compelling molecular media for digital data storage, and it is superior to the conventional electronic memory devices in theoretical retention time, power consumption, storage density, and so forth. However, uncertainties in the in vitro DNA synthesis and sequencing, along with its conjugation chemistry and preservation conditions can lead to severe errors and data loss, which limit its practical application. To maintain data integrity, complicated error correction algorithms and substantial data redundancy are usually required, which can significantly limit the efficiency and scale-up of the technology. Herein, we summarize the general procedures of the state-of-the-art DNA-based digital data storage methods (e.g. write, read, and preservation), highlighting the uncertainties involved in each step as well as potential approaches to correct them. We also discuss challenges yet to overcome and research trends in the promising field of DNA-based data storage.
- Subjects :
- 0303 health sciences
AcademicSubjects/SCI00010
business.industry
Information Storage and Retrieval
DNA
02 engineering and technology
Data loss
Biology
021001 nanoscience & nanotechnology
Replication (computing)
Field (computer science)
03 medical and health sciences
Digital Data Storage
Data redundancy
Data integrity
Computer data storage
Genes, Synthetic
Genetics
Biochemical engineering
Survey and Summary
0210 nano-technology
business
Error detection and correction
030304 developmental biology
Subjects
Details
- ISSN :
- 13624962 and 03051048
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Nucleic Acids Research
- Accession number :
- edsair.doi.dedup.....3684e77e98a61c85e1ba0b3c122531a5
- Full Text :
- https://doi.org/10.1093/nar/gkab230