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Subthalamic Nucleus Subregion Stimulation Modulates Inhibitory Control
- Source :
- Cerebral cortex communications, 1(1):tgaa083, Cerebral Cortex Communications
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Patients with Parkinson’s disease (PD) often experience reductions in the proficiency to inhibit actions. The motor symptoms of PD can be effectively treated with deep brain stimulation (DBS) of the subthalamic nucleus (STN), a key structure in the frontal–striatal network that may be directly involved in regulating inhibitory control. However, the precise role of the STN in stopping control is unclear. The STN consists of functional subterritories linked to dissociable cortical networks, although the boundaries of the subregions are still under debate. We investigated whether stimulating the dorsal and ventral subregions of the STN would show dissociable effects on ability to stop. We studied 12 PD patients with STN DBS. Patients with two adjacent contacts positioned within the bounds of the dorsal and ventral STN completed two testing sessions (OFF medication) with low amplitude stimulation (0.4 mA) at either the dorsal or ventral contacts bilaterally, while performing the stop task. Ventral, but not dorsal, DBS improved stopping latencies. Go reactions were similar between dorsal and ventral DBS STN. Stimulation in the ventral, but not dorsal, subregion of the STN improved stopping speed, confirming the involvement of the STN in stopping control and supporting the STN functional subregions.
- Subjects :
- Dorsum
Parkinson's disease
Deep brain stimulation
medicine.medical_treatment
Stimulation
Motor symptoms
03 medical and health sciences
0302 clinical medicine
Inhibitory control
inhibitory action control
Medicine
030304 developmental biology
General Environmental Science
subthalamic nucleus
0303 health sciences
business.industry
medicine.disease
deep brain stimulation
nervous system diseases
Subthalamic nucleus
surgical procedures, operative
nervous system
Parkinson’s disease
General Earth and Planetary Sciences
Original Article
business
therapeutics
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 26327376
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Cerebral Cortex Communications
- Accession number :
- edsair.doi.dedup.....368344acb943dc703e7ecb60e2b1c632