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Expression of α and β tubulin genes during the asexual and sexual blood stages of Plasmodium falciparum
- Source :
- Molecular and Biochemical Parasitology. 43:271-278
- Publication Year :
- 1990
- Publisher :
- Elsevier BV, 1990.
-
Abstract
- Malaria parasites switch to sexual development after a period of vegetative growth in the host's erythrocytes. This switch, vital for parasite transmission to mosquitoes, is little understood at the genetic level. Likely candidates for developmental control are the alpha- and beta-tubulin subunits required for microtubule assembly. We report here that the transcription of the alpha- and beta-tubulin genes in Plasmodium falciparum show a radically different pattern of transcription in the sexual and sexual phases of parasite growth. Our studies lead to the conclusion that three transcripts of the beta-tubulin gene differ by sequences in their 5'- or 3'-untranslated regions.
- Subjects :
- medicine.medical_specialty
Transcription, Genetic
Molecular Sequence Data
Plasmodium falciparum
Polymerase Chain Reaction
Tubulin
Transcription (biology)
Molecular genetics
parasitic diseases
medicine
Animals
Parasite hosting
Northern blot
Molecular Biology
Gene
Genetics
Base Sequence
biology
Exons
Blotting, Northern
biology.organism_classification
Introns
Gene Expression Regulation
biology.protein
Protozoa
Parasitology
Subjects
Details
- ISSN :
- 01666851
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Molecular and Biochemical Parasitology
- Accession number :
- edsair.doi.dedup.....368212a4ab24bc64962f7de68cb30a1a