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An investigation into the relationship between vigabatrin, movement disorders, and brain magnetic resonance imaging abnormalities in children with infantile spasms
- Source :
- Developmental Medicine & Child Neurology. 55:862-867
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Aim: we aimed to investigate the relationship between movement disorders, changes on brain magnetic resonance imaging (MRI), and vigabatrin therapy in children with infantile spasms. Method: retrospective review and brain MRI analysis of children enrolled in the International Collaborative Infantile Spasms Study (ICISS) who developed a movement disorder on vigabatrin therapy. Comparisons were made with controls within ICISS who had no movement disorder. Results: ten of 124 infants had a movement disorder and in eight it had developed on vigabatrin therapy. Two had a movement disorder that resolved on dose-reduction of vigabatrin, one had improvement on withdrawing vigabatrin, two had resolution without any dose change, and in three it persisted despite vigabatrin withdrawal. The typical brain MRI changes associated with vigabatrin therapy were noted in two infants. Ten control infants were identified. Typical MRI changes noted with vigabatrin were noted in three controls. Interpretation: it is possible that in two out of eight cases, vigabatrin was associated with the development of a movement disorder. In six out of eight cases a causal relationship was less plausible. The majority of infants treated with vigabatrin did not develop a movement disorder. MRI changes associated with vigabatrin do not appear to be specifically related to the movement disorder
- Subjects :
- Male
Pediatrics
medicine.medical_specialty
Movement disorders
Ataxia
genetic structures
Globus Pallidus
Tardive dyskinesia
Basal Ganglia
Vigabatrin
Epilepsy
Developmental Neuroscience
Cerebellum
medicine
Humans
Brain magnetic resonance imaging
Psychiatry
Retrospective Studies
Movement Disorders
medicine.diagnostic_test
Brain
Infant
Magnetic resonance imaging
Retrospective cohort study
medicine.disease
Magnetic Resonance Imaging
Pediatrics, Perinatology and Child Health
Anticonvulsants
Female
Neurology (clinical)
medicine.symptom
Psychology
Spasms, Infantile
Brain Stem
medicine.drug
Subjects
Details
- ISSN :
- 00121622
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Developmental Medicine & Child Neurology
- Accession number :
- edsair.doi.dedup.....367d2f02c96232f6bfd14f9f31830db5