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Thrombotic Microangiopathy Following Chemotherapy with S-1 and Cisplatin in a Patient with Gastric Cancer: A Case Report
- Source :
- In Vivo. 31:439-441
- Publication Year :
- 2017
- Publisher :
- Anticancer Research USA Inc., 2017.
-
Abstract
- Background Thrombotic microangiopathy (TMA) represents a spectrum of serious disorders characterized by occlusive microvascular thrombosis, thrombocytopenia and end-organ damage. TMA is associated with a broad range of conditions and is also a well-described complication of both cancer and its treatment. Case report A 77-year-old Japanese woman underwent S-1 and cisplatin chemotherapy for treatment of advanced gastric cancer with multiple lymph node and liver metastases. She was found with severe anemia and thrombocytopenia during the third course of chemotherapy. She was diagnosed with TMA based on thrombocytopenia, schistocytosis, hemolytic anemia and renal dysfunction. She underwent treatment with plasmapheresis; however, her response to treatment was poor and died on day 16 of hospitalization. The autopsy performed revealed microthrombi in the glomeruli and tubulonecrosis in the kidneys. Conclusion This is the first case report of TMA in association with the use of S-1 and cisplatin. Therapists have to take account of TMA when using S-1 and cisplatin treatment.
- Subjects :
- Hemolytic anemia
Oncology
Cancer Research
medicine.medical_specialty
Thrombotic microangiopathy
medicine.medical_treatment
030204 cardiovascular system & hematology
urologic and male genital diseases
Gastroenterology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Stomach Neoplasms
hemic and lymphatic diseases
Internal medicine
Humans
Medicine
Lymph node
Aged
Tegafur
Pharmacology
Cisplatin
Chemotherapy
Thrombotic Microangiopathies
business.industry
Cancer
medicine.disease
Drug Combinations
Oxonic Acid
medicine.anatomical_structure
Lymphatic Metastasis
030220 oncology & carcinogenesis
Female
Plasmapheresis
business
Complication
Research Article
medicine.drug
Subjects
Details
- ISSN :
- 17917549
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- In Vivo
- Accession number :
- edsair.doi.dedup.....367412e67520548e60b53934bbf3093a