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Quantitative expression data of human estrogen receptor α variants in non-functioning pituitary adenomas obtained by reverse transcription-digital polymerase chain reaction analysis
- Source :
- Data in Brief, Vol 33, Iss, Pp 106452-(2020), Data in Brief
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Expression profiles of gonadal steroid receptor variants have been reportedly associated with malignancy in breast and prostate cancers [1,2]. However, such associations with pituitary tumors remain unclear. Therefore, the expression levels of the wild-type ESR1 (ERα66) and the ESR1 variants (ERαi34, ERαi45c, and ERαΔ5) transcripts encoding constitutively active ERα proteins with C-terminal truncation in non-functioning pituitary adenomas (NFPAs) were evaluated using reverse transcription-digital polymerase chain reaction. The results revealed that the expression levels of the variants were approximately two orders of magnitude lower than that of ERα66 in NFPAs. These data were based on our previous article entitled "Accurate assessment of estrogen receptor profiles in non-functioning pituitary adenomas using RT-digital PCR and immunohistochemistry" [3].
- Subjects :
- estrogen receptor α variant
Estrogen receptor
Biology
lcsh:Computer applications to medicine. Medical informatics
RT-dPCR
law.invention
03 medical and health sciences
0302 clinical medicine
law
medicine
Digital polymerase chain reaction
Receptor
lcsh:Science (General)
Polymerase chain reaction
030304 developmental biology
Data Article
0303 health sciences
Multidisciplinary
ESR1
Pituitary tumors
medicine.disease
Reverse transcriptase
Cancer research
Immunohistochemistry
lcsh:R858-859.7
Estrogen receptor alpha
030217 neurology & neurosurgery
non-functioning pituitary adenomas
lcsh:Q1-390
Subjects
Details
- Language :
- English
- ISSN :
- 23523409
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Data in Brief
- Accession number :
- edsair.doi.dedup.....36581fa806465586590c2c90f19150ee