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The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma
- Source :
- PLoS ONE, Vol 7, Iss 11, p e49568 (2012), PloS one, PLoS ONE, PLoS ONE, 7 (11)
- Publication Year :
- 2012
- Publisher :
- Public Library of Science (PLoS), 2012.
-
Abstract
- Vascular endothelial growth factor A (VEGFA) plays a key role in the angiogenesis of human skin. Elevated levels of VEGFA are associated with several pathological conditions, including chronic inflammatory skin diseases and several types of skin cancer. In particular, squamous cell carcinoma (SCC) of the skin, the second most common skin cancer in the general population, is characterized by invasive growth, pronounced angiogenesis and elevated levels of VEGFA. The processing, turnover and production of VEGFA are extensively regulated at the post-transcriptional level, both by RNA-binding proteins and microRNAs (miRNAs). In the present study, we identified a new miRNA recognition element in a downstream conserved region of the VEGFA 3′-UTR. We confirmed the repressive effect of miR-361-5p on this element in vitro, identifying the first target for this miRNA. Importantly, we found that miR-361-5p levels are inversely correlated with VEGFA expression in SCC and in healthy skin, indicating that miR-361-5p could play a role in cancers. ISSN:1932-6203
- Subjects :
- Vascular Endothelial Growth Factor A
Skin Neoplasms
Angiogenesis
Cancer Treatment
Gene Expression
lcsh:Medicine
Human skin
0302 clinical medicine
Molecular Cell Biology
Gene Order
lcsh:Science
Skin Tumors
3' Untranslated Regions
Skin
Regulation of gene expression
0303 health sciences
education.field_of_study
Multidisciplinary
Squamous Cell Carcinomas
10177 Dermatology Clinic
3. Good health
Gene Expression Regulation, Neoplastic
Vascular endothelial growth factor A
Oncology
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Medicine
Antiangiogenesis Therapy
Research Article
endocrine system
Population
Malignant Skin Neoplasms
610 Medicine & health
Dermatology
1100 General Agricultural and Biological Sciences
Biology
Cell Line
Molecular Genetics
03 medical and health sciences
1300 General Biochemistry, Genetics and Molecular Biology
microRNA
Genetics
Cancer Genetics
Cancer Detection and Diagnosis
medicine
Humans
Gene Regulation
Squamous Cell Carcinoma
education
030304 developmental biology
1000 Multidisciplinary
Base Sequence
Three prime untranslated region
lcsh:R
Computational Biology
Cancers and Neoplasms
medicine.disease
MicroRNAs
Mutation
Immunology
Cancer research
lcsh:Q
Skin cancer
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 7
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....365220935b6e9e6babb113fa8d187200