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Design of a microfluidic chip consisting of micropillars and its use for the enrichment of nasopharyngeal cancer cells
- Source :
- Oncology Letters
- Publication Year :
- 2018
- Publisher :
- Spandidos Publications, 2018.
-
Abstract
- The aim of the present study was to discuss the design of a microfluidic chip consisting of columns, and its use for the enrichment of nasopharyngeal cancer (NPC) cells. A microfluidic chip experiment was simulated using FLUENT software. Within the microfluidic chip, aptamers were bound to the reaction chamber (consisting of columns) using a biotin-avidin system. Cell suspension was introduced into the reaction chamber to capture NPC cells. NPC cells were subsequently eluted, and the capture rate of the cells was calculated. The modified aptamer-bound microfluidic chip was able to capture NPC cells with a capture rate of ~90%. The modified aptamer-bound microfluidic chip has a wide range of potential applications for the diagnosis of NPC.
- Subjects :
- Cancer Research
Materials science
Fluent software
Aptamer
010401 analytical chemistry
nasopharyngeal cancer
microfluidic chip consisting of columns
aptamer
Nanotechnology
Articles
02 engineering and technology
021001 nanoscience & nanotechnology
01 natural sciences
Suspension culture
0104 chemical sciences
stomatognathic diseases
Oncology
Microfluidic chip
otorhinolaryngologic diseases
Reaction chamber
0210 nano-technology
Nasopharyngeal cancer
Subjects
Details
- ISSN :
- 17921082 and 17921074
- Database :
- OpenAIRE
- Journal :
- Oncology Letters
- Accession number :
- edsair.doi.dedup.....364d40e217afc8f5c0423e7bbacd68d1