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Immunohistochemical localization of calcitonin gene-related peptide and cotransmitters in a subpopulation of post-ganglionic neurons in the porcine inferior mesenteric ganglion
- Source :
- Acta histochemica. 92(2)
- Publication Year :
- 1992
-
Abstract
- Summary Applying double-fluorescence immunohistochemistry, adrenergic and non-adrenergic postganglionic sympathetic neurons, in the porcine inferior mesenteric ganglion (IMG) are subdivided according to size and cotransmitter content. Calcitonin gene related peptide (CGRP)-immunoreactive (IR) neurons are demonstrated to belong to the non-adrenergic, i.e. tyrosine hydroxylase- and DOPAmine-s-hydroxylase-(DsH)-negative subpopulation of postganglionic perikarya. Virtually all of the CGRP-IR postganglionic neurons exhibit colocalization with somatostatin (SOM), and, some of them with neuropeptide tyrosine (NPY). Additionally, NPY-, SOM-, and NPY/SOM-IR subpopulations of adrenergic and non-adrenergic neurons are observed. CGRP-immunoreactivity is seen in dense networks of intraganglionic varicose nerve fibres, adjacent to the TH-and SOM-IR neurons. NPY-IR perikarya are sparsely supplied by CGRP-IR fibres. SOM- and NPY-IR nerve fibres also exist in the inferior mesenteric ganglion. The functional relevance of CGRP-IR postganglionic neurons, as well as target organs of these neurons remain to be elucidated.
- Subjects :
- medicine.medical_specialty
Histology
Inferior mesenteric ganglion
Tyrosine 3-Monooxygenase
Swine
Calcitonin Gene-Related Peptide
Post-ganglionic
Adrenergic
Dopamine beta-Hydroxylase
Biology
Calcitonin gene-related peptide
Internal medicine
medicine
Animals
Neurons
Ganglia, Sympathetic
Tyrosine hydroxylase
Neuropeptides
Colocalization
Cell Biology
General Medicine
Immunohistochemistry
humanities
Mesenteric Arteries
Endocrinology
Somatostatin
nervous system
Female
Subjects
Details
- ISSN :
- 00651281
- Volume :
- 92
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Acta histochemica
- Accession number :
- edsair.doi.dedup.....363e3db5f725857a298a4e5f00ddaa74